A comparative study on the influence of biapenem and meropenem on valproic acid blood concentration
10.3760/cma.j.issn.1008-5734.2015.02.016
- VernacularTitle:比阿培南与美罗培南对丙戊酸血药浓度影响的比较研究
- Author:
Lian TANG
1
;
Zhiwei ZHUANG
;
Fuli ZHAO
;
Chen YANG
;
Erning SHANG
Author Information
1. 215002,苏州市立医院药学部
- Publication Type:Journal Article
- Keywords:
Valproic acid;
Meropenem;
Biapenem;
Plasma concentration;
Drug interactions
- From:
Adverse Drug Reactions Journal
2015;(2):126-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the influence of carbapenems such as biapenem and meropenem on valproic acid( VPA)blood concentration. Methods The clinical data of patients with symptomatic epilepsy and infections who were hospitalized in Suzhou Municipal Hospital during January 2008 to December 2013,and received concomitant therapy with VPA and biapenem or meropenem were collected and analyzed retrospectively. These patients were divided into biapenem group and meropenem group. The information of general clinical data and medication were recorded. VPA blood concentration,seizures and clinical treatment before and after the combination with carbapenems were compared between the two groups. Results A total of 79 cases were enrolled in the analysis. Six patients were treated with meropenem and biapenem successively at more than one month intervals,clinical data during the period of different carbapenems use were included in different groups. There were 37 cases in the biapenem group and 48 cases in the meropenem group;clinical data had no statistical significance between the 2 groups. The VPA blood concentration of biapenem group and meropenem group were significantly decreased. The VPA blood concentrations in biapenem group were higher than that of meropenem group(13. 3 ± 6. 2)mg/L vs(10. 7 ± 7. 0)mg/L,P= 0. 046). The mean decrease of VPA blood concentrations in biapenem group was also less than that of meropenem group(70. 6 ± 9. 6% vs 78. 8 ± 8. 8%,P=0. 010). The VPA blood concentrations of six patients treated with meropenem and biapenem successively were significantly decreased. The blood concentrations were also higher when combined with biapenem compared to meropenem. The rate of seizures had no significant difference between the 2 groups( 29. 7% vs 35. 4%,P =0. 749 ). Conclusions Both biapenem and meropenem could decrease VPA blood concentrations significantly. Biapenem had less impact on VPA blood concentration compared to meropenem,but also increased the risk of seizures.
