Research progress of high mobility group box 1 in the pathogenesis of depressive disorder
- VernacularTitle:高迁移率族蛋白1在抑郁症发病机制中的研究进展
- Author:
Meng LIANG
1
;
Bingying DU
1
;
Cunxiu FAN
1
;
Xiaoyan LU
1
;
Yongjie LIAN
1
;
Xiaoying BI
1
Author Information
- Publication Type:Journal Article
- Keywords: Depressive disorder; Inflammation; High mobility group proteins
- From: Chinese Journal of Psychiatry 2020;53(3):267-270
- CountryChina
- Language:Chinese
- Abstract: Depressive disorder is a prevalent psychiatric disorder with complicated pathological mechanism.It has been proved that aseptic inflammation of the central nervous system (CNS) plays an important role in the pathogenesis of depressive disorder. High mobility group box 1 (HMGB1) is a non-histone DNA-binding protein widely presented in eukaryotic nuclei that can induce the central inflammatory response when released into the extracellular space, which in turn participates in the onset of depressive disorder. Therefore, this paper reviewed the researches of HMGB1 in depressive disorder, in order to provide reference for further research.
