Fluorouracil-induced colitis and hand-foot syndrome
10.3760/cma.j.issn.1008-5734.2015.02.024
- VernacularTitle:氟尿嘧啶致结肠炎及手足综合征
- Author:
Li XU
1
;
Yujie ZHANG
1
;
Juan FENG
1
;
Tao DONG
1
;
Biaoluo WANG
1
;
Jie LIANG
1
;
Kaichun WU
1
Author Information
1. 西京医院消化内科/肿瘤生物学国家重点实验室, 西安,710032
- Publication Type:Journal Article
- Keywords:
Fluorouracil;
Colitis;
Hand-foot syndrome
- From:
Adverse Drug Reactions Journal
2015;(2):150-151
- CountryChina
- Language:Chinese
-
Abstract:
A 48-year-old female patient with abdominal pain was diagnosed as"acute pancreatitis"at the local hospital and received IV infusion of fluorouracil 1. 0 g,pantoprazole sodium 120 mg and amino acid(18AA)250 ml once daily. On day 11 of treatments,she developed mucous bloody stool with tenesmus,fever with alopecia, and exfoliative changes of her hand-foot skin. Ulcerative colitis was considered. Drugs above mentioned were stopped and glucocorticoid treatment was given. After 3 months of hormone treatment,her mucous bloody stool relieved,the abdominal pain exacerbated,and alopecia and hand-foot damages was not improved. Then,she came to Xijing Hospital. Pathological examination of living tissue in colonic mucosa showed no crypt structure changes. According to the patient's history,changes of hair and hand-foot skin,and her pathological examination results,the drug-induced colitis and hand-foot syndrome was considered. The dosage of glucocorticoid was gradually reduced and stopped at last. Propylamine acyl glutamine was given to repair the intestinal mucosa and keep the balance of the gut bacteria and intestinal nutrition,metronidazole for anti-infection,and enteral nutrition for supportive treatments. After 5 days of treatments,the patient's symptoms of abdominal pain and mucous bloody stool relieved,hair loss and skin damage recovered gradually. At 4 months of follow up,abdominal pain and bloody stool did not recur and her hair and skin returned to normal.
