A clinical randomized controlled study of aerobic exercise on the cognitive function of patients with depression in their remission
10.3760/cma.j.cn113661-20201127-00485
- VernacularTitle:有氧运动干预抑郁症缓解期患者认知功能的临床随机对照研究
- Author:
Qianqian CHEN
1
;
Ruizhi XU
1
;
Xiaojing WANG
1
;
Tongxian CHEN
1
;
Yiping TANG
1
Author Information
1. 台州市第二人民医院心身科 317200
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Exercise therapy;
Cognition;
Randomized controlled trial
- From:
Chinese Journal of Psychiatry
2021;54(1):25-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the efficacy of aerobic exercise on the improvement of cognitive function in patients with depression in remission stage.Methods:The discharged patients with depression in remission stage were randomly divided into exercise group ( n=63) and non-exercise group ( n=62). The exercise group received aerobic exercise training on the basis of drug maintenance therapy, and the non-exercise group received drug maintenance therapy only. Neuropsychological tests were used to evaluate participant′s cognitive functions at baseline, 8 weeks and 16 weeks by using digital span-antegrade (Digit Span-Sequential Order, DS-SO), digital span-inversion (Digit Span-Reversed Order, DS-RO), visual regeneration (Visual Reproduction, VR) of the Chinese version of the Wechsler memory scale, connection test (Trail Making Test, TMT, continuous performance test (Continuous Performance Task, CPT) and word fluency test (Verbal Fluency Test, VFT). Difference comparisons between the two groups were conducted. Simple effect analysis was used to compare the differences. Results:There was no significant difference in the scores of cognitive function between the two groups at baseline. After 8 weeks of aerobic training, the cognitive function of the exercise group was partially improved compared with the non-exercise group, and there were significant differences in TMT-A score ((51.4±19.1) s vs.(56.9±21.9) s, t=4.53, P<0.01), VFT score (20.4±5.6 vs.18.7±5.4, t=1.73, P=0.09) and TMT-B score ((80.3±37.3) s vs.(96.6±38.4) s, t=-2.41, P=0.01). After 16 weeks of aerobic training, the cognitive function of the exercise group was significantly better than that of the non-exercise group. TMT-A ((44.2±16.4) s vs.(53.4±19.0) s, t=-2.90, P<0.01), CPT (98.8±10.7 vs.91.4±11.8, t=3.67, P<0.01), VFT score (23.1±5.4 vs.19.4±5.2, t=3.90, P<0.01), and TMT-B ((77.9±30.7) s vs. (92.9±35.6) s, t=-2.52, P=0.01) were significantly better than those of the non-exercise group. Compared with the baseline, simple effect analysis showed that there were significant differences in the scores of TMT-A, CPT and TMT-B at the week-8 ( F=22.46, 17.47, 32.92, all P<0.01), and in the scores of TMT-A, CPT, DS-RO, VR, VFT and TMT-B at week-16 in the exercise group ( F=23.31, 18.46, 4.37, 5.58, 12.24, 28.83,all P<0.01). The scores and the changes of TMAT-A, CPT, VFT, TMT-B, DS-SO and DS-RO in the exercise group were significantly different from those in the non-exercise group. Conclusion:16-week aerobic exercise can effectively improve the cognitive function of patients with depression in remission stage.
