Subcortical volumes and ketamine’s antidepressant efficacy in major depressive disorder
10.3760/cma.j.cn113661-20200306-00089
- VernacularTitle:皮质下灰质体积与氯胺酮抗抑郁作用的关系
- Author:
Yanling ZHOU
1
;
Wei ZHENG
;
Weijian LIU
;
Chengyu WANG
;
Yanni ZHAN
;
Xiaofeng LAN
;
Bin ZHANG
;
Hanqiu LI
;
Yuping NING
Author Information
1. 广州医科大学附属脑科医院（广州市惠爱医院）早期干预科 510370
- Publication Type:Journal Article
- Keywords:
Ketamine;
Depressive disorder;
Forecasting;
Subcortical volumes
- From:
Chinese Journal of Psychiatry
2020;53(3):229-236
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the relationship between subcortical volumes and ketamine’s antidepressant effects.Methods:Forty-five depressive patients with treatment resistance or suicide ideation were involved and received six infusions of ketamine for two weeks（0.5 mg/kg，thrice-weekly）. Depressive symptoms were assessed by Montgomery-?sberg Depression Rating Scale (MADRS) and suicide ideation was assessed by Beck Scale for Suicide Ideation-part one (SSI-Ⅰ). Subcortical volumes underwent 3.0T-weighted MRI. The Freesurfer software was used to process the T 1 images, which used a set of automated sequences to analyze subcortical volumes. Forty-five healthy controls were collected and their subcortical volumes were compared with the patients’ volumes. Linear regression analysis was used to determine the association between pre-treatment subcortical volumes and change in MADRS score as well as SSI scores after ketamine treatment (change=pre-treatment scores minus post-treatment scores). Results:In comparison to the healthy controls, depressive patients had decreased bilateral hippocampal volumes (Left:(2 993±276) mm 3vs. (2 785±263) mm 3， F=12.928， P=0.001； Right: (3 117±254) mm 3vs. (2 949±270) mm 3, F=8.217， P=0.005). Pre-treatment volumes of right thalamus were positively correlated with change in MADRS scores after six infusions in patients with treatment resistance （ B=0.009， t=3.434, P=0.002）. Conclusion:Six ketamine infusions exerted enhanced antidepressant effects in treatment-resistant depression patients with relatively larger thalamus. Volume of thalamus could be used as a biomarker of six ketamine’s antidepressants treatment outcome.
