Application of traditional Chinese medicine for treatment of atherosclerosis via targe-ting PPAR
10.20039/j.cnki.1007-3949.2025.06.001
- VernacularTitle:传统中药作为PPAR调节剂在动脉粥样硬化治疗中的应用
- Author:
Ying WU
1
;
Xueying ZHANG
1
;
Shoudong GUO
1
Author Information
1. 山东第二医科大学药学院脂代谢与动脉粥样硬化研究室,山东省 潍坊市 261053
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
peroxisome proliferator-activated receptor;
lipid homeostasis;
in-flammation;
cardiovascular diseases
- From:
Chinese Journal of Arteriosclerosis
2025;33(6):461-468
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is recognized as an inflammatory disease,and its development is regulated by multiple fac-tors,particularly dyslipidemia.Peroxisome proliferator-activated receptor(PPAR)regulate the expression of genes that are involved in lipid metabolism and inflammation;and they have three subfamily members including PPARα,PPARβ,and PPARγ.However,synthetic PPAR agonists exhibit ambiguous effects in atherosclerotic therapy and induce various side effects.Notably,recent studies demonstrate that traditional Chinese medicine(TCM)alleviate atherosclerotic cardiovascular diseases via suppressing hyperlipidemia and inflammation through regulation of PPAR signaling pathway.This article pri-marily reviews the regulatory effects of TCM on PPAR and their therapeutic effects on atherosclerosis,provides valuable in-formation for pharmacologists that are interested in searching for effective herbal prescriptions for atherosclerosis therapy and for clinicians that are interested in prevention and treatment of atherosclerotic cardiovascular diseases using TCM.
