Agranulocytosis(grade Ⅳ)due to topotecan
10.3760/cma.j.issn.1008-5734.2015.03.018
- VernacularTitle:托泊替康致Ⅳ度粒细胞缺乏
- Author:
Yilan FU
1
;
Liping YANG
1
;
Qian GONG
1
;
Ni LIU
1
;
Qing ZHU
1
;
Lizhi CAO
1
Author Information
1. 湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院药学部临床药学室,长沙,410013
- Publication Type:Journal Article
- Keywords:
Topotecan;
Agranulocytosis
- From:
Adverse Drug Reactions Journal
2015;(3):229-230
- CountryChina
- Language:Chinese
-
Abstract:
A 50-year-old male with non-Hodgkin lymphoma received topotecan combined with cisplatin( IV infusion of topotecan 2 mg,from the first day to the fourth day;IV infusion of cisplatin from the first day to the third day,a course of treatment was 3 weeks ). Blood routine examination before chemotherapy revealed the following levels:white blood cell( WBC)4. 21 × 109/L,neutrophil counts ( NEU)2. 85 × 109/L. On day 2 after the end of administration of topotecan,the patient developed nausea, obvious weak. Blood routine examination showed WBC 1. 88 × 109/L,NEU 0. 99 × 109/L. On day 3,his body temperature increased to 38. 7 ℃,blood routine examination showed WBC 0. 38 × 109/L,NEU 0. 10 × 109/L. The patient was diagnosed as agranulocytosis(Ⅳdegree)accompanied infective fever. He received recombinant human granulocyte colony-stimulating,sulbactam and cefoperazone,fluconazole,moxifloxacin, piperacillin and tazobactam,and isepamicin,successively. Twelve days later,his body temperature returned to normal. Twenty-three days later,blood routine examination showed WBC 5. 86 × 109/L,NEU 4. 57 × 109/L.
