Mental disorder due to methylprednisolone in patients with systemic lupus erythematosus:report of 4 cases
- VernacularTitle:甲泼尼龙致系统性红斑狼疮患者精神障碍4例
- Author:
Hao REN
1
;
Jinjun ZHAO
1
;
Jingli LIN
1
;
Danyu CUI
1
;
Weinan LAI
1
;
Qin HUANG
1
;
Min YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Methylprednisolone; Lupus erythematosus,systemic; Mental disorders
- From: Adverse Drug Reactions Journal 2015;(3):232-234
- CountryChina
- Language:Chinese
- Abstract: Four female patients( aged 17,14,25,and 20,respectively)with systemic lupus erythematosus( cases 1 and 2 were complicated with type IV lupus nephritis ) received high-dose methylprednisolone pulse therapy,which included an IV infusion of methylprednisolone 0. 5 g daily for 3 days,and then instead of prednisone 1-2 mg·kg-1 ·d-1 orally. Five to eighteen days after administration, the four patients developed the symptoms of mental disorders,such as exciting,garrulous,anxiety,mania, hardly fall asleep,even delusion of persecution and suicidal tendency. The four patients returned to normal completely after 19 days to 2. 5 months by decreasing the dosage of the steroid gradually and the treatment with sedatives and antipsychotic drugs.
