Characteristics of feedback negativity of anhedonia in depression
10.3760/cma.j.cn113661-20190515-00177
- VernacularTitle:抑郁症愉快感缺失的脑电反馈负波特征
- Author:
Haiyan WU
1
;
Xinyu WANG
1
;
Chenyang GAO
1
;
Xiangfei HONG
1
;
Lei DING
1
;
Zhenying QIAN
1
;
Huifeng ZHANG
1
;
Ting SHEN
1
;
Daihui PENG
1
Author Information
1. 上海交通大学医学院附属精神卫生中心心境障碍科 200030
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Bipolar disorder;
Evoked Potentials;
Negative feedback;
Anhedonia
- From:
Chinese Journal of Psychiatry
2020;53(3):237-242
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to explore the clinical features and electrophysiological mechanism of depression through event-related potential analysis.Method:Temporal Experience of Pleasure Scale (TEPS) was used to evaluate anticipatory (TEPS-A) and consummatory (TEPS-C) pleasurable experience among 53 participants (20 patients with major depressive disorder (MDD), 14 patients with bipolar depression Ⅱ (BD) and 19 health controls (HC)). Hamilton Depression Scale (HAMD) and Brief Screening Scale for Dementia (BSSD) were used to evaluate patients’ clinical characteristics. All subjects completed gambling task according to the instructions. Meanwhile, continuous electroencephalogram （EEG) was recorded, and feedback negativity in event-related potential was analyzed.Results:Firstly, compared with HC group, the scores of TEPS, TEPs-A and TEPs-C in MDD and BD groups were decreased ( P<0.01). Secondly, the FN amplitude wave decreased significantly in MDD group ((-0.138±2.562) μV), compared with HC ((-2.569±2.598) μV) and BD group ((-2.251±0.954) μV), P<0.05. Thirdly, in contrast to HC ((10.778±6.967) μV) and BD ((10.284±5.540) μV), the MDD group ((6.069±4.353) μV) displayed blunted responses to gain feedback; For the loss feedback, no significant difference was shown among the three groups. Moreover, correlation analysis showed that, for the MDD group, consummatory anhedonia measured by TEPS-C were associated with reduction in response to gain feedback ( r=-0.501 ，P=0.024). Conclusions:Patients with depressive episode FN in MDD was negatively correlated with the score of consummatory pleasurable experience by having a lack of pleasure, which was manifested as the decrease of both anticipatory pleasurable experience and consummatory pleasurable experience. Patients with MDD showed decreased reward sensitivity and decreased FN amplitude, while patients with BD Ⅱ showed no similar trend. The changes in EEG indicated underpinning mechanism of anhedonia in depression.
