Progress in research of the antidepressant effect of scopolamine
10.3760/cma.j.cn113661-20200325-00140
- VernacularTitle:东莨菪碱快速抗抑郁的研究进展
- Author:
Xuxia MA
1
;
Tianyu WANG
1
;
Yingying YUE
1
;
Yonggui YUAN
1
Author Information
1. 东南大学附属中大医院心理精神科 东南大学医学院，南京 210009
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Scopolamine
- From:
Chinese Journal of Psychiatry
2020;53(3):258-262
- CountryChina
- Language:Chinese
-
Abstract:
The cholinergic system has been implicated in the pathophysiology of depression. The nonselective muscarinic acetylcholine receptor antagonist scopolamine manifested rapid and robust antidepressant effects. This review seeks to find available clinical and basic evidence related to the rapid antidepressant effect of scopolamine, meanwhile, summarizes possible mechanisms, side effects and biomarkers for efficacy outcomes underlying the antidepressant effect of scopolamine.
