Cholestatic liver disease and portal hypertension
- VernacularTitle:胆汁淤积性肝病与门静脉高压
- Author:
Li CHEN
1
;
Changqing YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Cholestasis; Liver Diseases; Hypertension,Portal
- From: Journal of Clinical Hepatology 2025;41(7):1251-1255
- CountryChina
- Language:Chinese
- Abstract: Cholestatic liver disease(CLD)is a group of rare chronic liver diseases with the core feature of biliary system damage,and the progression of CLD is often complicated by portal hypertension(PH),which significantly affects the prognosis of patients.This article systematically elaborates on the pathophysiological relationship between CLD and PH,with a focus on the core mechanisms such as bile acid toxicity,fibrosis-driven mechanisms,and vascular remodeling,and it also summarizes the comprehensive management strategy based on evidence-based medicine that integrates etiological treatment and PH intervention.Further studies are needed to analyze the CLD-PH molecular network,develop precise targeted therapies,and promote the application of artificial intelligence in disease stratification and prognosis prediction,so as to improve the clinical outcomes of patients.
