Clinical trial of dexamethasone combined with tranexamic acid in the treatment of patients with postoperative bleeding induced fibrinolysis in benign prostatic hyperplasia
10.13699/j.cnki.1001-6821.2025.01.004
- VernacularTitle:地塞米松联合氨甲环酸治疗前列腺增生术后出血致纤溶亢进患者的临床研究
- Author:
Zhao-yue LIU
1
;
Hui-fang YAN
;
Shan-shan JIN
Author Information
1. 衡水市人民医院,泌尿外科,河北衡水 053000
- Publication Type:Journal Article
- Keywords:
dexamethasone injection;
aminomethylcyclopentanoic acid injection;
prostate hyperplasia surgery;
hyperfibrinolysis;
coagulation factor;
safety evaluation
- From:
The Chinese Journal of Clinical Pharmacology
2025;41(1):16-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of dexamethasone injection combined with tranexamic acid injection in the treatment of patients with hyperfibrinolysis caused by bleeding after prostatic hyperplasia.Methods Patients with hyperfibrinolysis caused by hemorrhage after prostatic hyperplasia were randomly divided into control group and treatment group.The control group was given 1 g·d-1 tranexamic acid intravenously.On the basis of the control group,the treatment group was given dexamethasone 10 mg,intravenous injection,q12 h.Both groups were treated continuously for 5 days.The clinical efficacy,coagulation factor level,quality of life(QOL)score,international prostate symptom score(IPSS),and safety were compared between the two groups.Results In the treatment group,52 cases were enrolled,2 cases fell off,and finally 50 cases were included in the statistical analysis.In the control group,51 cases were enrolled,1 case fell off,and finally 50 cases were included in the statistical analysis.After treatment,the total effective rates of treatment group and control group were 94.00％(47 cases/50 cases)and 72.00％(36 cases/50 cases),respectively,and the difference was statistically significant(P＜0.05).After treatment,the partial thromboplastin time of treatment group and control group were(35.12±4.38)and(49.14±5.61)s;the prothrombin time were(12.78±1.67)and(16.10±1.94)s;D-dimer levels were(350.42±25.90)and(380.90±37.10)μg·L-1;QOL scores were(1.16±0.37)and(2.26±0.78)points,IPSS were(4.48±1.22)and(16.12±3.67)points,respectively.The differences of above indexes were statistically significant between two groups(all P＜0.05).The adverse drug reactions of two groups were mainly abdominal pain,anemia and headache.The incidences of total adverse drug reactions in treatment group and control group were 6.00％and 16.00％,respectively,without statistical significance(P＞0.05).Conclusion Dexamethasone injection combined with tranatemylic acid injection has a definitive clinical efficacy in the treatment of patients with bleeding induced hyperfibrinolytic hyperplasia after prostatic hyperplasia,which can significantly improve the coagulation function of patients,relieve symptoms,without increasing the incidence of adverse drug reactions.
