Mechanisms and intervention strategies of angiogenesis disorders in diabetic foot ulcers
10.3760/cma.j.cn501225-20241204-00474
- VernacularTitle:糖尿病足溃疡血管形成障碍的机制及干预策略
- Author:
Ke TAO
1
;
Tao CAO
;
Tong HAO
Author Information
1. 温州医科大学附属第一医院创面修复与再生医学中心创面修复科，温州 325015
- Publication Type:Journal Article
- Keywords:
Diabetic foot;
Neovascularization, pathologic;
Wound healing;
Cellular microenvironment;
Peripheral nerves
- From:
Chinese Journal of Burns
2025;41(2):120-126
- CountryChina
- Language:Chinese
-
Abstract:
Nerve and vascular damage are important factors affecting the occurrence and development of diabetic foot ulcer (DFU). Lower extremity vascular injury combined with microangiogenesis disorder caused by various factors including hyperglycemia, neurotrophic impairment, ischemia, hypoxia, and infection is an important reason for delayed healing of DFU wound. Angiogenesis is a pathophysiological process in which endothelial cells, endothelial progenitor cells, and stem cells rebuild microvascular network under the regulation of various cytokines and microenvironment, which is a key step in the process of DFU wound healing. The mechanisms of DFU wound angiogenesis disorders are complex and diverse. This article summarizes the new progress of DFU microvascular injury mechanism and intervention strategies from three aspects including angiogenesis microenvironment, neuronutrition, and cell function to provide new ideas for the treatment of DFU.
