Severe erythema multiforme caused by iodixanol injection
10.3760/cma.j.issn.1008-5734.2014.01.014
- VernacularTitle:碘克沙醇注射液致重症多形红斑型药疹
- Author:
Ni YAN
1
;
Yirui WANG
1
;
Xia WANG
1
;
Shenglin WU
1
;
Xia DU
1
Author Information
1. 430050,武汉市第五医院药学部
- Publication Type:Journal Article
- Keywords:
Iodixanol injection;
Drug eruption
- From:
Adverse Drug Reactions Journal
2014;16(1):45-46
- CountryChina
- Language:Chinese
-
Abstract:
An 82-year-old male patient with coronary atherosclerosis heart disease received iodixanol injection 60 ml for arteriography.On day 2 after operation,the patient developed erythema multiforme and itching.Aspirin,bisoprolol,atorvastatin,and clopidogrel were stopped and anti-allergy treatments were given.Eight days later,the symptoms worsened gradually.Delayed anaphylactic reaction induced by iodixanol was considered.Laboratory examination showed the following results:white blood cell count 10.1 × 109/L,neutrophils 0.79,eosinophils 0.02,high sensitivity C reaction protein 13.9 mg/L,and procalcitonin 0.189 μg,/L.Severe erythema multiforme was diagnosed.The patient's symptoms improved after treatments with methylprednisolone sodium succinate,sodium fusidate,mouth care (lidocaine + dexamethasone + sodium bicarbonate solution),wet dressing for lip (normal saline + gentamicin + dexamethasone).
