Acute pancreatitis due to celecoxib
10.3760/cma.j.issn.1008-5734.2014.01.013
- VernacularTitle:塞来昔布致急性胰腺炎
- Author:
Chengping JIANG
1
;
Shengqian LI
1
Author Information
1. 川北医学院附属医院药剂科, 四川省南充市,637000
- Publication Type:Journal Article
- Keywords:
Celecoxib;
Pancreatitis
- From:
Adverse Drug Reactions Journal
2014;16(1):43-44
- CountryChina
- Language:Chinese
-
Abstract:
A 43-year old woman with scapulohumeral periarthritis received celecoxib 0.2 mg twice daily for 2 weeks.She developed upper abdominal persistent dull pain,distension,nausea and vomiting two hours after the last administration.Laboratory tests showed the following values:serum amylase 1 822 U/L,amylopsin 1 529 U/L,lipase 1 410 U/L,white blood cell count 12.7 × 109/L,neutrophils 0.74,and lymphocytes O.16.Abdominal ultrasound examination and magnetic resonance cholangiopancreatography showed a diffusely enlarged pancreas and fluid exudation around pancreas.The patient was diagnosed as acute pancreatitis.Celecoxib was withdrawn.Thirteen days after the therapy with jejunitas,nutritional supporting,enzyme inhibition,acid suppression,and anti-infection,her symptoms of abdominal pain and distensionwere disappeared.Laboratory tests showed the following values:serum amylase 86 U/L,amylopsin 48 U/L,lipase 55 U/L,white blood cell count 7.2 × 109/L,neutrophils 0.65,and lymphocytes 0.32.AbdominalCT showed caputpancreatis,corpora pancreatic,and pancreatic tail were located on the same level,the pancreatic shape and size were normal.
