Lower gastrointestinal bleeding associated with docetaxel
10.3760/cma.j.issn.1008-5734.2013.03.016
- VernacularTitle:多西他赛相关下消化道大出血
- Author:
Bing SUN
1
;
San-tai SONG
1
;
Ze-fei JIANG
1
;
Zhou HUANG
1
;
Tao WANG
1
;
Shao-hua ZHANG
1
;
Shi-kai WU
1
Author Information
1. 军事医学科学院附属医院乳腺肿瘤科,北京,100071
- Publication Type:Journal Article
- Keywords:
Docetaxel;
Gastrointestinal hemorrhage
- From:
Adverse Drug Reactions Journal
2013;15(3):167-168
- CountryChina
- Language:Chinese
-
Abstract:
A 55-year-old female patient received an Ⅳ infusion of docetaxel 140 mg for lymph nodes,bones,and liver metastases after operation of breast cancer.In the morning of day 6 after chemotherapy,she developed a lot of fresh blood in her stool.Her heart rate was 120 beats/min.Her routine blood tests showed the following levels:white blood cell count 0.9 × 109/L,hemoglobin 103 g/L,platelet count 62 × 109/L.She received an Ⅳ injection of hemocoagulase 2 U and an Ⅳ infusion of aminomethylbenzoic acid 0.2 g immediately.In the noon of the same day,a lot of fresh blood appeared in the patient's stool again and she felt palpitation and fatigue.Routine blood tests showed a white blood cell count of0.5 × 109/L,a hemoglobin level of 75 g/L,and a platelet count of 52 × 109/L.She received enema with Yunnanbaiyao (云南白药) 1 g + lyophilized thrombin powder 4000 U + iced saline 100 ml every 2 h; continuous Ⅳ infusion of somatostatin 3 mg for 12 h; transfusion of suspended red blood cells 2 U and apheresis platelets 1 U.The electron colonoscopy scanning showed multiple rectal ulcers with one site of bleeding.Then endoscopic hemostasis was performed,and no bleeding recurred.
