Severe erythema multiforme induced by tegafur, gimeracil and oteracil potassium capsules
10.3760/cma.j.issn.1008-5734.2013.03.013
- VernacularTitle:替吉奥胶囊致重症多型红斑型药疹
- Author:
Nian-bo GUAN
1
;
Cheng-hui JIA
1
Author Information
1. 中国中医科学院广安门医院肿瘤科,北京,100053
- Publication Type:Journal Article
- Keywords:
Tegafur;
Oteracil;
Drug eruptions;
Erythema multiforme
- From:
Adverse Drug Reactions Journal
2013;15(3):162-163
- CountryChina
- Language:Chinese
-
Abstract:
A 57-year-old male patient with pancreatic cancer received postoperative chemotherapy with an Ⅳ infusion of gemcitabine 1.6 g on days 1 and 8 combined with 3 capsules of tegafur,gimeracil and oteracil potassium orally (each capsule contains tegafur 20 mg,gimeracil 5.8 mg,and oteracil potassium 19.6 mg) twice daily on days 1-14 and one cycle took 21 days.On day 3 of drug use,the patient developed generalized burning pain and his highest temperature reached 39.6 ℃.Sporadic prunosus pruritus appeared in his limbs,chest,and back.Tegafur,gimeracil and oteracil potassium capsules were stopped immediately and gemcitabine was continued.On day 5 of drug use,the inside of his limbs,chest,and back were covered a large area of erythema multiforme,of which experienced vesicular in the center,red bulla fusing into lamella,and rupture and wound exposure,accompanied by erosive oral mucosa at the same time.Symptomatic treatments were given and,two weeks later,the rashes basically subsided.One week later,he received two cycles of combination chemotherapy with gemcitabine and fluorouracil and two cycles of capecitabine for chemotherapy as well and the rashes did not recur.
