Research progress on anti-tumor effect of traditional Chinese medicine intervention on post-transcriptional regulation of HuR
- VernacularTitle:中医药干预HuR转录后调控的抗肿瘤作用研究进展
- Author:
Liu-qing YANG
1
;
Wei-xia LI
1
;
Xiao-yan WANG
1
;
Ming-liang ZHANG
1
;
Hui ZHANG
1
;
Ya-li WU
1
;
Jin-fa TANG
1
Author Information
- Publication Type:Journal Article
- Keywords: tumor; HuR; post-transcriptional regulation; mR-NA stability; traditional Chinese medicine; molecular mecha-nism
- From: Chinese Pharmacological Bulletin 2025;41(8):1413-1418
- CountryChina
- Language:Chinese
- Abstract: Cancer is the main cause of death,and drug therapy has greatly improved the effectiveness of anti-tumor treatment.However,there are problems such as high adverse reactions and the risk of developing drug resistance after long-term use.There is an urgent need to seek new drug targets.Human antigen R(HuR),as an RNA binding protein,promotes the whole process of tumor occurrence,development and metastasis through post transcriptional regulation of mRNA stability,and HuR is general-ly highly expressed in tumor tissue,making it a new target for an-ti-tumor therapy and a standard for prognosis evaluation.Tradi-tional Chinese medicine formulas and their various chemical components can inhibit tumor proliferation,induce tumor cell ap-optosis,inhibit angiogenesis,suppress immune escape,and re-verse tumor drug resistance by regulating HuR activity.This re-view summarizes the importance of HuR in regulation of tumor progression,as well as analyzes the mechanisms of the antitumor effects through active ingredients of Chinese medicine with the regulation of HuR.It is expected to provide new ideas for tumor therapy and guidance for the development of HuR-targeted anti-tumor drugs.
