The frequency and risk factors of calcified nodule in patients with coronary artery disease:a meta-analysis
10.3969/j.issn.1004-8812.2025.07.004
- VernacularTitle:冠状动脉疾病患者钙化结节的患病率与危险因素:一项荟萃分析
- Author:
Song-yuan GAO
1
;
Wei-jie HOU
;
Bin ZHANG
;
Fang-fang FAN
;
Yan-jun GONG
;
Bo ZHENG
Author Information
1. 北京大学第一医院心血管内科,北京 100034
- Publication Type:Journal Article
- Keywords:
Calcified nodule;
Coronary artery disease;
Intravascular ultrasound;
Optical coherence tomography
- From:
Chinese Journal of Interventional Cardiology
2025;33(7):383-396
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate the prevalence of calcified nodule(CN)among patients with coronary artery disease(CAD)and identify the possible risk factors associated with an increased CN risk.Methods Databases include PubMed,Web of Science and Embase was conducted to identify studies reporting the prevalence and/or risk factors of CN.For this databases,the search was from inception to January 1,2024.Data analyses was performed using R statistical Software 4.2.2.Results A total of 46 studies involving 17 926 patients were included.Among them,13 studies with 4 187 patients reported both the prevalence and associated risk factors.The overall prevalence of CN was found to be 5.72％(95％CI 4.47％-7.31％),while in studies reporting both the prevalence and risk factors,the CN prevalence was slightly higher at 8.72％(95％CI 6.43％-11.71％).Hypertension(OR 1.75,95％CI 1.29-2.37),diabetes(OR 1.84,95％CI 1.46-2.33),chronic kidney disease(OR 2.50,95％CI 1.67-3.74),and hemodialysis(OR 7.77,95％CI 4.77-12.67)were associated with an elevated CN risk(all P＜0.001).Conversely,obesity(OR 0.39,95％CI 0.18-0.83)and history of smoking(OR 0.61,95％CI 0.47-0.80)were linked to a decreased CN risk(both P＜0.05).Conclusions The overall prevalence of CN is relatively low among patients with CAD.However,the prevalence of CN is influenced by a variety of clinical factors.Further research is warranted to elucidate the underlying mechanisms.
