Epidermolysis bullosa after treatment with levofloxacin, cefoperazone sodium and sulbactam sodium, clindamycin
10.3760/cma.j.issn.1008-5734.2013.02.013
- VernacularTitle:左氧氟沙星、头孢哌酮钠舒巴坦钠与克林霉素相关大疱性表皮松解症
- Author:
Can-ping ZHOU
1
;
Qi-zhi LU
;
Chun-yan LIN
;
Xue-mei QUAN
Author Information
1. 广西江滨医院临床药学室,南宁,530021
- Publication Type:Journal Article
- Keywords:
Ofloxacin;
Cefoperazone;
Clindamycin;
Epidermolysis bullosa
- From:
Adverse Drug Reactions Journal
2013;15(2):100-101
- CountryChina
- Language:Chinese
-
Abstract:
A 62-year-old female patient received an Ⅳ infusion of levofloxacin 0.5 g once daily for urinary tract infection,red rash developed on inner side of her upper limbs and back on the same day.The levofloxacin was discontinued and anti-allergic treatments were given.The next day,she received an Ⅳ infusion of cefoperazone sodium and sulbactam sodium 4.0 g every 8 hours and clindamycin 0.75 g once daily for pulmonary infection.After six days,she experienced oral mucosal erosion,diffused red swelling and flaccid vesicles appeared on her multiple body regions,and partial exfoliation occurred.Epidermolysis bullosa was diagnosed.Antibiotics were discontinued and an Ⅳ infusion of methylprednisolone 80 mg once daily was given.Her skin symptoms relieved after 3 days.The next day,she received an Ⅳ infusion of amikacin sulfate 0.4 g every 8 hours for a secondary infection of the skin.The rash appeared again on the same day.Glucocorticoid combined human immunoglobulin and supportive treatments were given.Her symptoms of skin gradually improved.
