New progress in the study of the oncogenic mechanisms of HBV-associated hepatocellular carcinoma
10.3760/cma.j.issn.1674-2397.2025.02.003
- VernacularTitle:HBV相关肝细胞癌致癌机制研究新进展
- Author:
Yilin MA
1
Author Information
1. 浙江大学医学院附属第一医院感染病科 传染病重症诊治全国重点实验室 国家感染性疾病临床医学研究中心，杭州 310003
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Hepatitis B virus;
Carcinogenic mechanisms
- From:
Chinese Journal of Clinical Infectious Diseases
2025;18(2):96-117
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus（HBV）infection is one of the leading causes of hepatocellular carcinoma（HCC）. Although vaccination and antiviral therapy have reduced HBV infection rates in some regions，the incidence of HBV-associated HCC（HBV-HCC）remains high. Therefore，in-depth research into the carcinogenic mechanisms of HBV-HCC not only helps elucidate the key molecular events by which the virus drives tumorigenesis but also provides a theoretical basis for early diagnosis，risk stratification，and targeted therapy. This article explores the carcinogenic mechanisms of HBV-HCC from multiple perspectives，including HBV proteins and genetic variations，gene expression in liver tissue，viral genome integration，cell signaling pathways，malignant transformation and heterogeneity of liver stem cells，host genetic factors，and intra-organ iron metabolism abnormalities，offering insights for clinical and scientific research.
