Research progress of mitochondrial quality control in myocardial fibrosis
- VernacularTitle:线粒体质量控制在心肌纤维化中的研究进展
- Author:
Xiao-bin ZHAO
1
;
Wen-fang JIN
;
Hai-feng ZHANG
;
Wen-yu LIU
;
Ying-dong LI
;
Xin-ke ZHAO
Author Information
- Publication Type:Journal Article
- Keywords: mitochondrial quality control; mitochondrial bio-synthesis; mitochondrial dynamics; mitochondrial autophagy; mitochondrial protein degradation; myocardial fibrosis
- From: Chinese Pharmacological Bulletin 2025;41(8):1419-1423
- CountryChina
- Language:Chinese
- Abstract: Myocardial fibrosis(MF)is the leading cause of car-diac insufficiency.Its complex pathogenesis and lack of effective treatment are key issues to be addressed in the cardiovascular field.Mitochondrial quality control system(MQC)is an impor-tant mechanism for eukaryotic cells to maintain the stability of mitochondrial form,quantity and quality.MQC disorders,which are characterized by low level of mitochondrial biogenesis,exces-sive mitochondrial oxidative stress,mitochondrial autophagy de-fect and mitochondrial dynamics disorder,play a crucial role in mediating the pathophysiological process of MF.Consequently,this article reviews the role of MQC in MF pathogenesis and the latest research,in order to better understand the molecular mech-anism of MF and provide reference for the development of more natural drugs in the future.
