The relationship between the type of hypertriglyceridemia and the severity and prognosis of acute pancreatitis
10.3760/cma.j.cn115455-20240706-00575
- VernacularTitle:高三酰甘油血症类型与急性胰腺炎病情严重程度和预后的关系
- Author:
Shutao LIU
1
;
Chunlei CHEN
1
;
Yuxin ZHANG
1
Author Information
1. 亳州市人民医院急诊外科，亳州 236800
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Dyslipidemias;
Prognosis;
Severity of illness
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(12):1117-1121
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between the type of hypertriglyceridemia(HTG) and the severity and prognosis of acute pancreatitis (AP).Methods:A total of 112 AP patients with HTG diagnosed and treated in Bozhou People's Hospital from June 2022 to June 2024 were retrospectively selected as the study objects, the AP severity and complication rate of patients with different types of HTG were compared. According to the discharge status of AP patients, they were divided into poor prognosis group (26 cases) and good prognosis group (86 cases). Univariate and multivariate Logistic regression were used to analyze the risk factors of poor prognosis in HTG patients with AP.Results:The main types of HTG in AP patients were type Ⅰ, type Ⅳ and type Ⅴ. The proportion of severe disease in AP patients with type Ⅰ HTG was higher than that of other HTG types, there were statistical differences ( P<0.05). The incidence of pancreatic pseudocyst and infectious pancreatic necrosis in AP patients with different HTG types had no statistical differences ( P>0.05). The incidence of systemic inflammatory response syndrome and organ failure in AP patients with HTG type Ⅰ was higher than that with other HTG types, there were statistical differences ( P<0.05). The proportion of type I HTG and severe AP in the poor prognosis group were higher than those in the good prognosis group : 88.46%(23/26) vs. 68.60%(59/86), 76.92%(20/26) vs. 13.95%(12/86); the triglycerides (TG), very low-density lipoprotein (VLDL), total cholesterol (TC) and fasting plasma glucose (FPG) in the poor prognosis group were higher than those in the good prognosis group: (17.29 ± 3.48) mmol/L vs. (12.29 ± 2.45) mmol/L, (3.04 ± 0.46) mmol/L vs.(2.46 ± 0.68) mmol/L,(6.03 ± 1.13) mmol/L vs.(5.25 ± 1.23) mmol/L, (12.01 ± 1.67) mmol/L vs. (11.14 ± 1.82)mmol/L; while albumin and blood calcium were lower than those in the good prognosis group: (36.28 ± 1.53) g/L vs. (37.33 ± 1.65) g/L, (1.65 ± 0.57) mmol/L vs. (2.04 ± 0.72) mmol/L; there were statistical differences ( P<0.05). The results of single factor analysis showed that combined HTG type, AP severity, triglyceride (TG), very low density lipoprotein (VLDL), total cholesterol (TC), fasting blood glucose (FPG), albumin and blood calcium levels were risk factors affecting the prognosis of AP patients ( P<0.05). Multivariate Logistic regression analysis showed that combined HTG type, AP severity, TG, VLDL, TC, FPG, blood calcium and albumin levels were independent risk factors affecting the prognosis of AP patients ( P<0.05). Conclusions:The type of HTG is closely related to the severity and prognosis of AP patients. Among them, AP patients with type Ⅰ HTG have a higher rate of severe disease. The combination of type Ⅰ HTG, the severity of AP, and abnormal lipid metabolism indexes are all important independent risk factors affecting the prognosis of AP patients.
