Analysis of the relationship between the expression of DOG-1 and Ki67 and postoperative complications in patients with gastric neoplasms
10.3760/cma.j.cn115455-20240704-00566
- VernacularTitle:胃肿瘤患者DOG-1、Ki67表达与术后并发症的关系分析
- Author:
Yuna JIANG
1
;
Yamei BU
1
;
Wei ZHU
1
Author Information
1. 湖州市第一人民医院普外科，湖州 313000
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
DOG-1;
Ki67;
Postoperative complications
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(12):1113-1117
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between the expression of DOG-1 and Ki67 and postoperative complications in patients with gastric neoplasms.Methods:A total of 84 cases of gastric neoplasms admitted to Huzhou First People's Hospital from January 2022 to January 2024 were retrospectively selected as the study objects. All patients underwent surgical resection. The DOG-1 and Ki67 positive expression rates of cancer tissue and adjacent tissues were compared. According to the incidence of complications 1 month after surgery, the patients were divided into the non-complication group (58 cases) and the complication group (26 cases), and the positive expression rates of DOG-1 and Ki67 in the cancer tissues of the two groups were compared. Spearman correlation coefficient model was used to analyze the correlation between DOG-1 and Ki67 positive expression and complications. Logistic regression was used to analyze the risk factors of postoperative complications in patients with gastric neoplasms.Results:The positive expression rates of DOG-1 and Ki67 in the cancer tissues were higher than those in the adjacent tissues: 77.38% (65/84) vs. 15.48% (13/84), 73.81% (62/84) vs. 17.86%(15/84), there were statistical differences ( P<0.05).The positive expression rates of DOG-1 and Ki67 in difference maximum tumor diameter, TNM stage, lymph node metastasis, pathological grade, lymph vascular space infiltration had statistical significance ( P<0.05). The positive expression rates of DOG-1 and Ki67 in the complication group were higher than those in the non-complication group: 92.31%(24/26) vs. 70.69%(41/58),88.46%(23/26) vs. 67.24%(39/58), there were statistical differences ( P<0.05).Correlation analysis showed that the positive expressions of DOG-1 and Ki67 were positively correlated with postoperative complications ( r = 0.741, 0.582, P<0.05). Logistic regression model showed that maximum tumor diameter, TNM stage, lymph node metastasis, pathological grade, lymphovascular space infiltration, DOG-1 and Ki67 were risk factors for postoperative complications in patients with gastric neoplasms ( P<0.05). Conclusions:In gastric cancer tissues, the positive expression rates of DOG-1 and Ki67 are high, and they are related to postoperative complications, which are influential factors leading to postoperative complications in patients with gastric neoplasms.
