Research progress of arginine metabolism in the regulation of mesenchymal stem cell function

VernacularTitle:精氨酸代谢调控间充质干细胞功能的研究进展
Author: KERANMU SAITIERGULI ¹ ; Lei QIAN ¹ ; Siyi DING ¹ ; MAHELIMUHAN HANATI ¹ ; Xueer YANG ¹ ; Hao JIA ¹
Author Information

1. 上海交通大学基础医学院生物化学与分子细胞生物学系,上海市肿瘤微环境与炎症重点实验室,上海 200025
Publication Type:Journal Article
Keywords: mesenchymal stem cells; arginine metabolism; cell differentiation; inflammation
From: Journal of Shanghai Jiaotong University(Medical Science) 2025;45(7):910-915
CountryChina
Language:Chinese
Abstract: Mesenchymal stem cells(MSCs)are adult stem cells that exist in bone marrow,fat,cord blood,bone,muscle and other tissues.MSCs not only have the unique self-renewal ability and multidirectional differentiation potential of stem cells,but also have the function of immune regulation.Arginine is a conditionally essential amino acid,and its metabolic regulation is essential for maintaining cell function and overall health.In MSCs,arginine metabolism may have a certain effect on cell proliferation,differentiation,inflammatory response,and tumor development.This article summarizes the effects of arginine metabolism on the differentiation,inflammation,immunity,and tumor development in different types of MSCs,discusses new strategies for the treatment of metabolic syndrome,and provides new ideas for the treatment of inflammatory diseases and tumors by MSCs from the perspective of arginine metabolism.