Efficacy analysis in elderly and frail newly diagnosed multiple myeloma patients with dose-reduced lenalidomide/melphalan/prednisone acetate regimens
10.3969/j.issn.1674-8115.2025.07.002
- VernacularTitle:剂量减低的来那度胺/美法仑/醋酸泼尼松方案治疗老年虚弱新诊断多发性骨髓瘤的效果分析
- Author:
Xingli ZHANG
1
;
Jie TIAN
;
Jing LUO
;
Qian LIU
;
Wanyan OUYANG
;
Hongchun QIU
;
Yan WANG
;
Jianqing MI
Author Information
1. 上海交通大学医学院附属瑞金医院血液科,上海血液学研究所,国家转化医学研究中心(上海),上海 200025;江苏省昆山市第三人民医院血液科,昆山 215300
- Publication Type:Journal Article
- Keywords:
elderly frail;
newly diagnosed multiple myeloma;
lenalidomide;
melphalan;
prednisone acetate;
dose-reduced
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2025;45(7):815-822
- CountryChina
- Language:Chinese
-
Abstract:
Objective·To investigate the efficacy and safety of a dose-reduced,all-oral lenalidomide/melphalan/prednisone acetate(RMP)regimen in elderly and frail patients with newly diagnosed multiple myeloma(NDMM).Methods·Elderly and frail NDMM patients who visited the Department of Hematology of Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,and the Third People's Hospital of Kunshan from April 2018 to March 2024 were retrospectively included.Clinical data and laboratory indicators were collected,and all patients were treated with the RMP regimen.SPSS 27.0 and R software were used for statistical analysis.Independent t-test was applied to normally distributed quantitative data,Mann-Whitney U test to non-normally distributed quantitative data,and x2 test and Fisher's exact probability method to qualitative data.Kaplan-Meier survival curves and Log-rank test were used for survival analysis.Results·Among the 22 elderly and frail NDMM patients treated with RMP,the median age was 76.3(68.4,95.0)years,and the median follow-up time was 25.5 months.The overall response rate(ORR)was 68.2%,and the rate of≥very good partial response(VGPR)was 36.4%.The median progression-free survival(PFS)was 20.53 months.The median PFS in the≤75-year-old group was 25.23(95%CI 12.95?37.52)months,while in the>75-year-old group it was 18.23(95%CI 14.86?21.61)months.There was no significant difference between the two groups.The median PFS in the≥partial response(PR)group was 20.67(95%CI 13.57?27.76)months,and in the
