Research progress in the application of optogenetics in ophthalmology
10.3760/cma.j.cn511434-20240912-00340
- VernacularTitle:光遗传学技术在眼科应用的研究进展
- Author:
Tianhong WU
1
;
Zhigang CHEN
1
;
Xue HAN
1
;
Hanmu GUO
1
;
Peirong LU
1
Author Information
1. 苏州大学附属第一医院眼科, 苏州 215006
- Publication Type:Journal Article
- Keywords:
Optogenetics;
Retinal diseases;
Optic nerve diseases;
Visual function studies;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2025;41(8):645-651
- CountryChina
- Language:Chinese
-
Abstract:
Optogenetics, a technique for the precise modulation of cellular activity, has unveiled its distinctive application value within ophthalmology. Optogenetics achieves the light-controlled activation or inhibition of retinal cell functions through precise genetic introduction of light-sensitive proteins, paving new avenues for the treatment of irreversible vision impairment. Optogenetics has emerged as an effective treatment for retinal degenerative diseases and optic nerve damage, it has also made substantial contributions to the realm of visual function research. Furthermore, the integration of optogenetics with light-controlled stem cell technology and light-controlled gene editing technology has unveiled its immense potential in clinical translation. With the advancement of technology and the deepening of clinical practice, optogenetics holds broad prospects within ophthalmology and is poised to offer innovative therapeutic strategies for patients with visual impairments.
