Correlation analysis of macular microvascular structure and intraocular fluidin patients with diabetic macular edema
10.3760/cma.j.cn511434-20241113-00425
- VernacularTitle:糖尿病黄斑水肿患眼黄斑微血管结构改变与眼内液的相关性分析
- Author:
Jie GAO
1
;
Zhihui ZHAO
;
Huiwen PANG
;
Feng ZHANG
;
Lei SUN
;
Fanmin SUN
;
Weijie ZHANG
;
Tao WANG
Author Information
1. 山东第二医科大学临床医学院, 潍坊 261000
- Publication Type:Journal Article
- Keywords:
Diabetic macular edema;
Macular microvascular structure;
Optical coherence tomography;
Optical coherence tomography angiography;
Intraocular fluid test
- From:
Chinese Journal of Ocular Fundus Diseases
2025;41(5):343-348
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe and analyze the correlation between the changes of macular microvascular structure and the level of intracocular fluid cytokines in patients with diabetic macular edema (DME).Methods:A prospective clinical study. From December 2022 to June 2024, 20 patients with 25 eyes of DME diagnosed by Department of Ophthalmology of Linyi People's Hospital were included in the study. Among them, 14 males had 17 eyes and 6 females had 8 eyes. Age was (55.08±10.34) years. Optical coherence tomography (OCT) and OCT angiography (OCTA) were used to scan the macular region at a range of 6 mm×6 mm. Central retinal thickness (CRT), blood flow density of superficial retinal capillary plexus (SCP) and area of fovea avascular zone (FAZ) were measured. The anterior aqueous humor was extracted before the first intravitreal injection of anti-vascular endothelial growth factor (VEGF), the concentrations of interleukin (IL-6), IL-8, VEGF, vascular cell adhesion molecule (VCAM), placental growth factor (PLGF) and monocyte chemotactic protein-1 (MCP-1) were detected. The correlation between macular microvascular structure and aqueous humor cytokines was analyzed by Spearman correlation analysis.Results:The CRT of the affected eyes was (617.40±167.64) μm, the SCP flow density was (39.56±1.55)%, and the FAZ area was (0.46±0.13) mm 2. The concentrations of IL-6, IL-8, VEGF, VCAM, PLGF and MCP-1 in aqueous humor were (301.36±690.52), (29.15±20.56), (71.37±29.32) and (5 621.22±7 241.06), (72.40±13.43), (464.07±163.26) pg/ml, respectively. Correlation analysis showed that there was a significant positive correlation between CRT and the concentrations of aqueous cytokines VEGF and PLGF ( r=0.460, 0.462, P<0.05). FAZ area was positively correlated with VEGF and MCP-1 concentrations ( r=0.414, 0.465; P<0.05). There was a significant negative correlation between SCP blood flow density and IL-6 ( r=0.401, P<0.05). Conclusion:There was a significant correlation between the morphological structure of macular area and the damage degree of microvessels around macular area in DME patients and the concentration of aqueous cytokines.
