Research progress of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 in diabetic retinopathy
10.3760/cma.j.cn511434-20240626-00241
- VernacularTitle:长链非编码RNA转移相关肺腺癌转录本1在糖尿病视网膜病变中的研究进展
- Author:
Bin HU
1
;
Yanming TIAN
Author Information
1. 石河子大学医学院研究生院, 石河子 832003
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Long non-coding RNA;
MALAT1;
Molecular mechanism;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2025;41(1):76-80
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy (DR) is a serious complication of diabetes mellitus that not only impairs vision and quality of life but has also emerged as a leading cause of blindness in working-age individuals. Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (LncMALAT1) is a non-coding RNA molecule that regulates gene expression and has been implicated in the pathogenesis and progression of DR. It exerts its effects through the modulation of various pathological processes, including inflammation, oxidative stress, angiogenesis, and apoptosis. Notably, alterations in the expression levels of LncMALAT1 may serve as potential biomarkers for the early diagnosis of DR. Furthermore, interventions targeting LncMALAT1, employing antioxidants, anti-angiogenic agents, traditional Chinese medicine, and gene therapy, present promising avenues for its potential development as an effective therapeutic target for DR.
