Premixed insulin twice daily dosing regimen for Chinese people with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2024.12.006
- VernacularTitle:适合中国2型糖尿病患者的每日2次预混胰岛素剂量分配方案研究
- Author:
Yuxin HUANG
1
;
Cuiping JIANG
1
;
Xiaoming TAO
1
Author Information
1. 200040上海,复旦大学附属华东医院内分泌科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Premixed insulin;
Continuous glucose monitoring system
- From:
Chinese Journal of Diabetes
2024;32(12):907-911
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the optimal dose of twice daily premixed insulin regimen in Chinese patients with type 2 diabetes mellitus(T2DM). Methods A total of 361 T2DM patients admitted to the department of endocrinology in Huadong hospital affiliated to Fudan university from March 2017 to October 2021 were selected. All patients received stable doses of premixed insulin twice daily and had HbA1c<7％. Continuous blood glucose monitoring confirmed that TIR was>70％ and TBR was<1％. According to different insulin formulations,it was divided into Regular/NPH 30 group (n=161),Aspart 30 group (n=156),and Lispro 25 group (n=44). Clinical characteristics,total insulin dose,pre-breakfast insulin dose,pre-dinner insulin dose,and pre-breakfast/pre-dinner insulin ratio were compared. Pearson correlation analysis was used to analyze the correlation between total insulin dose and other indicators. Multiple linear regression analysis was used to analyze the influencing factors of the total insulin dose. Results The mean dose of total insulin,pre-breakfast insulin,and pre-dinner insulin was (30.6±8.6)U/d,(18.3±5.1)U/d,and (12.3±4.2)U/d,respectively. The median of insulin dose per kg was 0.4(0.4,0.5)U/d,and pre-breakfast/pre-dinner insulin ratio was 1.5(1.3,1.8). Pearson correlation analysis showed that total insulin dose was associated with BMI,HbA1c,FPG,and ALT. Multiple linear regression analysis showed that BMI,FPG,HbA1c,and ALT were independent factors of total insulin dose. Conclusions The initial dose of premixed insulin can be allocated at a ratio of 3∶2 before breakfast and before dinner in Chinese people with T2DM,not 1∶1.
