Research progress on the mechanism and treatment of endoplasmic reticulum stress in diabetic retinopathy
10.3760/cma.j.cn511434-20240723-00279
- VernacularTitle:内质网应激在糖尿病视网膜病变中的作用机制及治疗研究进展
- Author:
Weiwen HU
1
;
Qiong ZHOU
1
Author Information
1. 南昌大学第一附属医院眼科 南昌大学江西医学院, 南昌 330006
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Endoplasmic reticulum stress;
Unfolded protein response;
Inositol-requiring protein-1;
Protein kinase RNA-like endoplasmic reticulum
- From:
Chinese Journal of Ocular Fundus Diseases
2025;41(1):69-75
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy (DR), a neurovascular complication of diabetes, presents a multifaceted pathogenesis that encompasses numerous biological processes and molecular mechanisms. Endoplasmic reticulum stress (ERS) plays a critical role in the maintenance of cellular homeostasis, and diabetic neuromicroangiopathy is driven by high glucose, which activated ERS through the promotion of protein misfolding, oxidative stress, and disturbances in calcium homeostasis. ERS activates the unfolded protein response, thereby influencing the onset and progression of DR through modulating mitochondria-associated endoplasmic reticulum membranes, autophagy, apoptosis, microvascular function, oxidative stress, and inflammation pathways. Currently, the principal interventions against ERS comprise the modulation of the ERS signalling axis and its interactions with associated pathological processes such as autophagy, oxidative stress, and inflammation, through pharmacological and molecular mechanisms. These interventions are directly or indirectly shown to inhibit persistent ERS and are demonstrated to ameliorate DR. With the in-depth study of ERS and the research and development of various drugs for ERS, it is expected to bring novel insights and strategies for DR management in the future.
