Estrogen metabolism and postmenopausal breast cancer:clinical research progress
10.7659/j.issn.1005-6947.2024.11.017
- VernacularTitle:雌激素代谢与绝经后乳腺癌的临床研究进展
- Author:
Yanshou ZHANG
1
;
Zhifen YANG
;
Lihua ZHENG
;
Yunjiang LIU
Author Information
1. 河北医科大学第四医院乳腺中心,河北石家庄 050011;河北省肿瘤微环境与耐药重点实验室,河北 石家庄 050011
- Publication Type:Journal Article
- Keywords:
Breast Neoplasms;
Postmenopause;
Estrogens;
Metabolism;
Review
- From:
Chinese Journal of General Surgery
2024;33(11):1897-1903
- CountryChina
- Language:Chinese
-
Abstract:
Endogenous estrogen is currently considered a major risk factor for postmenopausal breast cancer. Under the catalysis of various enzymes,estrogen interacts through multiple metabolic pathways to produce various metabolites. The imbalance of estrogen and its metabolites in the body can induce physiological changes that may play a dual role in the development of breast cancer. However,due to the relatively low estrogen levels in postmenopausal women and the limitations of existing measurement methods in terms of specificity,accuracy,and reproducibility,the precise role of different estrogen metabolic pathways and their metabolites in the etiology of postmenopausal breast cancer remains unclear. Therefore,a deeper understanding of the estrogen metabolism pathways and their metabolites in the occurrence and progression of postmenopausal breast cancer may provide new insights for its prevention and treatment. Here,the authors review recent research progress on estrogen metabolism and postmenopausal breast cancer.
