Chlorogenic acid alleviates neurobehavioral disorders and brain injury in rats with subarachnoid hemorrhage
10.16557/j.cnki.1000-7547.2024.05.008
- VernacularTitle:绿原酸减轻蛛网膜下腔出血大鼠的神经行为障碍和脑损伤
- Author:
Guangzhi HAO
1
;
Zhen WANG
1
;
Zuolin SHI
1
;
Yushu DONG
1
Author Information
1. 中国人民解放军北部战区总医院神经外科,沈阳 110016
- Publication Type:Journal Article
- Keywords:
chlorogenic acid(CGA);
subarachnoid hemorrhag(SAH);
oxidative stress;
neuroprotection;
rat
- From:
Chinese Journal of Neuroanatomy
2024;40(5):588-592
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Cerebral hemorrhage can lead to neuronal cell death,nervous system disorder and permanent disability.Chlorogenic acid(CGA)has antioxidant,anti-inflammatory and anti-apoptotic properties.This study was to investigate the neuroprotective effect of CGA on subarachnoid hemorrhage(SAH)in rats.Methods:SAH was induced by carotid artery puncture in male adult rats.CGA(30 mg/kg)was injected intraperitoneally 2 h after SAH.Neurologi-cal outcomes were assessed 24 h after SAH by modified Garcia scores and the beam balance test.The brain edema was evaluated by dry-wet ratio method.Oxidative stress was assessed by measuring reactive oxygen species(ROS)and su-peroxide dismutase(SOD)activity in rat cortex using commercial kits.Results:SAH caused severe neurobehavioral defects and cerebral edema in rats.The level of ROS in cerebral cortex increased,while the activity of SOD decreased.However,CGA treatment improved the neurobehavioral deficits induced by SAH,while reducing ROS levels and enhan-cing SOD activity.Conclusion:CGA plays a neuroprotective role through anti-oxidative stress.
