Progress on vaccine development for porcine reproductive and respiratory syn-drome
10.16303/j.cnki.1005-4545.2025.06.30
- VernacularTitle:猪繁殖与呼吸综合征疫苗研究进展
- Author:
Xiaobing HUANG
1
;
Aijun LIU
1
;
Ronghui XIE
1
;
Chuanliang ZHANG
1
Author Information
1. 浙江省动物疫病预防控制中心,浙江 杭州 311199
- Publication Type:Journal Article
- Keywords:
porcine reproductive and respiratory syndrome;
PRRSV;
vaccines
- From:
Chinese Journal of Veterinary Science
2025;45(6):1338-1347
- CountryChina
- Language:Chinese
-
Abstract:
Porcine reproductive and respiratory syndrome(PRRS),an infectious disease,poses a significant threat to the swine industry.The causative agent of the disease is porcine reproductive and respiratory syndrome virus(PRRSV),which primarily infects porcine alveolar macrophages and destroys the immune system.In the absence of specific antiviral drugs targeting PRRSV,vacci-nation is of paramount importance for the prevention and control of this disease.Currently,there are numerous types of PRRS vaccines,such as attenuated live vaccines,inactivated vaccines,sub-unit vaccines,DNA vaccines,vector vaccines,and so forth.However,only attenuated live virus and inactivated virus vaccines are widely employed for the prevention and control of PRRS.Live vac-cines offer relatively better protection effects,but they have weak cross-protection and pose safety concerns.Inactivated vaccines are safe but have poor immunogenicity.This article conducts a com-prehensive review of the advantages,disadvantages,and applicability of PRRS vaccines,including attenuated live vaccines,inactivated vaccines,subunit vaccines,vector vaccines,DNA vaccines,mR-NA vaccines,virus-like particle vaccines,etc.,aiming to provide a theoretical basis for the research and development of the next generation of PRRS vaccines.
