Rho/ROCK signaling pathway and its regulatory effects on viral replication and cell tight junctions
- VernacularTitle:Rho/ROCK信号通路调控病毒复制及细胞紧密连接的研究进展
- Author:
Shiqi SHAN
1
;
Simin WANG
1
;
Yuheng LI
1
;
Qian WENG
1
;
Tianyi YIN
1
;
Zhihua PEI
1
;
Kai WANG
1
;
Guixue HU
1
Author Information
- Publication Type:Journal Article
- Keywords: viruses; Rho/ROCK signal pathway; tight junction
- From: Chinese Journal of Veterinary Science 2025;45(6):1322-1328
- CountryChina
- Language:Chinese
- Abstract: Rho proteins and the Rho-associated protein kinase(ROCK)signaling pathway are cruci-al components of intracellular signaling cascades.Rho proteins,which belong to the small GTPase family,play a pivotal role in regulating essential elements of the cytoskeleton within cells.ROCK functions as a downstream effector protein kinase of Rho,modulating various biological processes,including cell morphology,migration,and proliferation.Recent studies have underscored the signifi-cance of the ROCK signaling pathway in the replication of a diverse group of viruses.Furthermore,it has been discovered that some viruses disrupt cellular contraction,adhesion,and migration through the Rho/ROCK pathway,subsequently influencing the immune response triggered by vi-ral infections and affecting the tight junctions between cells.This article primarily reviews the re-search progress regarding the Rho/ROCK signaling pathway and its key signaling molecules,Rho and ROCK,in terms of their activation and regulation of viral replication and tight junction pro-teins between cells.
