Prenatal BPA exposure in maternal rabbits impairs reproductive function in F1 fe-male offspring through oxidative stress and inflammatory responses
10.16303/j.cnki.1005-4545.2025.06.27
- VernacularTitle:妊娠期母兔双酚A暴露通过氧化应激和炎症损害F1代雌兔生殖功能
- Author:
Qianhui ZHAO
1
;
Jialu PAN
;
Yanan CHUO
;
Chenggong LIU
;
Xiao WANG
;
Wanyu SHI
;
Yongzhan BAO
Author Information
1. 河北农业大学动物医学院,河北保定 071001
- Publication Type:Journal Article
- Keywords:
reproductive toxicity;
F1 generation of female rabbits;
reproductive hormones;
endocrine disruptors
- From:
Chinese Journal of Veterinary Science
2025;45(6):1314-1321
- CountryChina
- Language:Chinese
-
Abstract:
Bisphenol A(BPA)is an environmental endocrine disruptor commonly found in industri-al products such as plastics,resin coatings,and paper coatings,and it poses potential reproductive hazards.Despite extensive research,studies examining its effects on the F1 generation of rabbits are limited.This study established a BPA exposure model in pregnant female rabbits to investigate its impact on reproductive hormones,apoptosis,oxidative stress,inflammatory responses,and tissue integrity in weaned female offspring.The results indicate that BPA exposure induces oxidative stress and inflammation in F1 rabbits,disrupts hormonal balance,and affects antioxidant enzymes and inflammatory mediators through the modulation of the Nrf2 and NF-κB signaling pathways,ultimately leading to apoptosis and tissue damage.
