Research progress on the mechanism of iron death on blood retinal barrier in autoimmune uveitis

VernacularTitle:铁死亡在自身免疫性葡萄膜炎中对血视网膜屏障作用机制的研究进展
Author: Yangjing BAI ¹ ; Shuyang ZHONG
Author Information

1. 广西中医药大学研究生院,　南宁　530001
Publication Type:Journal Article
Keywords: Iron death; Autoimmune uveitis; Blood retinal barrier; Regulatory mechanisms; Review
From: Chinese Journal of Ocular Fundus Diseases 2024;40(12):980-985
CountryChina
Language:Chinese
Abstract: Iron death is an alternative to normal cell death and is regulated by a variety of cellular metabolic pathways. Iron death has become a hot topic of research because it can cause damage to various organs and degenerative diseases in the body. Metabolism, signalling pathways, endoplasmic reticulum stress, and immune cells can all affect the occurrence of iron death, and the blood-retina destruction induced by iron death plays an important role in autoimmune uveitis. Exploring the components of the blood-retina regulatory mechanism of iron death in autoimmune uveitis can lead to the search for targeted drug targets, which can provide a new research idea for the subsequent study of the diagnosis and treatment of autoimmune uveitis.