Research progress in the treatment of diabetic retinopathy
10.3760/cma.j.cn511434-20240923-00355
- VernacularTitle:糖尿病视网膜病变治疗的研究进展
- Author:
Chen XUE
1
;
Manhong XU
1
;
Xiaorong LI
1
Author Information
1. 天津医科大学眼科医院、眼视光学院、眼科研究所 国家眼耳鼻喉疾病临床医学研究中心天津市分中心 天津市视网膜功能与疾病重点实验室, 天津 300384
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Drug delivery;
Nano materials;
Gene therapy;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2025;41(1):56-62
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes, which seriously threatens the vision of patients. The pathogenesis of DR Is complex and involves many pathophysiological processes. At present, the treatment methods for DR Mainly include panretinal laser photocoagulation, vitrectomy and vitreous cavity injection, etc. However, each treatment method has certain limitations. In recent years, remarkable progress has been made in the field of drug treatment of DR, especially in anti-vascular endothelial growth factor drugs, anti-inflammatory drugs, anti-oxidative stress damage drugs, neuroprotective agents, gene therapy and stem cell therapy. These drugs not only improve the effectiveness of treatment, but also expand the range of treatment options. In addition, by carrying DR Treatment drugs on carriers such as nanoparticles, hydrogels and photosensitive materials, continuous and efficient release of drugs in the eye is achieved, thereby extending the time interval of administration and reducing the need for frequent treatment of patients. In the future, based on biomarker detection technology, it is expected to promote the development of personalized and precise treatment, which can develop more accurate treatment plans for patients and improve the efficacy.
