Clinical efficacy of Liraglutide combined with short-term insulin in newly diagnosed overweight/obese patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2024.12.007
- VernacularTitle:利拉鲁肽联合胰岛素短期强化治疗新诊断超重/肥胖2型糖尿病患者临床疗效的研究
- Author:
Fanglai WU
1
;
Daxiang HUANG
1
;
Xiufeng YANG
1
Author Information
1. 246003安庆市立医院内分泌科
- Publication Type:Journal Article
- Keywords:
Liraglutide;
Short-term intensive insulin therapy;
Diabetes mellitus,type 2;
Overweight;
Obesity
- From:
Chinese Journal of Diabetes
2024;32(12):912-917
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of Liraglutide(Lir) combined with short-term insulin intensive therapy in newly diagnosed overweight/obese patients with type 2 diabetes mellitus (T2DM). Methods A total of 144 newly diagnosed overweight/obese patients with T2DM admitted to the Endocrinology Department of Anqing Municipal Hospital from November 2022 to October 2023 were enrolled and randomly divided into intensive treatment(Int) group and Lir group with 72 cases in each group. The intensive Int group received oral Metformin tablets combined with subcutaneous injections of insulin before meals and insulin glargine before bedtime. The Lir group received subcutaneous injections of Liraglutide in addition to the Int group. The changes in blood pressure (BP),weight,BMI,WC,WHR,blood glucose(BG),blood lipids,SUA,HOMA-IR,HOMA-β,BG target time,insulin dosage and injection frequency,number of cases of meal-time insulin discontinuation and incidence of hypoglycemia before and after 1,4,and 12 weeks of treatment were evaluated and compared between the two groups. Results After 4 and 12 weeks of treatment,the BP,weight,BMI,WC and WHR were significantly lower than before treatment in the Lir group (P<0.05). 2 hPG at 1,4 and 12 weeks after treatment was significantly lower in Lir group than in Int group (P<0.05),and HbA1c after 12 weeks of treatment were significantly lower in Lir group than in Int group[(6.49±0.41)％ vs (8.31±0.75)％,P<0.05]. After 4 and 12 weeks of treatment,HDL-C,1 hC-P and HOMA-β were significantly higher in Lir group than in Int group,while TC,TG,LDL-C,SUA and HOMA-IR was significantly lower in Lir group than in Int group (P<0.05). The time for BG to reach the standard was significantly shorter in Lir group than in Int group[(4.23±1.55) vs (6.23±1.78) d,P<0.05].After treatment for 4 and 12 weeks,the basal insulin dosage decreased significantly. After treatment for 1,4,and 12 weeks,the insulin dosage during meals,the number of subcutaneous insulin injections,and the incidence of hypoglycemia were significantly reduced in Lir group than in Int group(P<0.05).The number of patients with discontinued insulin during meals has significantly increased (P<0.05). Conclusions In newly diagnosed overweight/obese patients with T2DM,the combination of Lir and insulin intensive therapy is beneficial in controlling BP,weight,BMI,WC,WHR,BG and SUA,promoting the improvement of pancreatic β cell function,shortening the time for BG to reach the standard,reducing insulin dosage and injection frequency,and lowering the risk of hypoglycemia.
