Role of m6A methylation modification in the occurrence and development of thyroid cancer:a review of research progress

VernacularTitle:m6A甲基化修饰在甲状腺癌发生发展中的作用研究进展
Author: Hongyou TIAN ¹ ; Lu CHENG ; Yan REN ; Jinyi GUO ; Jiaxiang MA ; Ailin SONG
Author Information

1. 兰州大学第二医院普通外科,甘肃兰州 730030;兰州大学第二临床医学院,甘肃兰州 730030
Publication Type:Journal Article
Keywords: Thyroid Neoplasms; N6-Methyladenosine; Prognosis; Review
From: Chinese Journal of General Surgery 2024;33(11):1883-1889
CountryChina
Language:Chinese
Abstract: Thyroid cancer (TC) is the most common endocrine malignancy. Although most patients have a favorable prognosis following standardized treatment,a subset experiences rapid disease progression and poor outcomes. Recent studies have identified N6-methyladenosine (m6A) methylation as the most prevalent RNA modification,which regulates RNA transcription,maturation,degradation,and stability,playing a role throughout the tumorigenesis process. Consequently,m6A methylation has been extensively studied in tumor treatment and prevention. Changes in m6A levels can lead to abnormal activation or inhibition of oncogenes or tumor suppressor genes in TC,thereby contributing to its initiation and progression. This review summarizes the concept of m6A methylation,the components and functions of its regulatory factors,its role in the development and progression of TC,and its implications for treatment and prognosis.