Recent advance in involvement of AMPA receptors in pathogenesis and treatment of migraine
10.3760/cma.j.cn115354-20240914-00572
- VernacularTitle:AMPA受体在偏头痛发病机制及治疗应用中的研究进展
- Author:
Xuan XU
1
;
Wenlu YE
1
;
Yixian HUANG
1
Author Information
1. 苏州大学附属第二医院神经内科，苏州 215004
- Publication Type:Journal Article
- Keywords:
Migraine;
Glutamate;
AMPA receptor;
Pathogenesis
- From:
Chinese Journal of Neuromedicine
2024;23(12):1279-1284
- CountryChina
- Language:Chinese
-
Abstract:
Migraine, a prevalent neurological disorder, obviously impairs the quality of life of the patients. α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are ion channel glutamate receptors that are responsible for facilitating rapid excitatory nerve signal transmission. Current study has revealed that AMPA receptors play a crucial role in migraine development. This article reviews the structure and function of AMPA receptors, relationship between AMPA receptors and migraine, and its application in migraine treatment, in order to provide new insights for pathogenesis and treatment of migraine.
