Regulatory effect of NRG-1/ErbB signaling pathway on peripheral neuromuscular system
10.3760/cma.j.cn115354-20241015-00632
- VernacularTitle:NRG-1/ErbB信号通路对周围神经肌肉系统的调控作用
- Author:
Ming MA
1
;
Yan WANG
;
Mingyue ZHAO
;
Shanhong WU
Author Information
1. 黑龙江中医药大学研究生院，哈尔滨 150040
- Publication Type:Journal Article
- Keywords:
Denervated muscle atrophy;
NRG-1/ErbB pathway;
Schwann cell;
Acetylcholine receptor
- From:
Chinese Journal of Neuromedicine
2025;24(2):207-212
- CountryChina
- Language:Chinese
-
Abstract:
After peripheral nerve injury, nerve regeneration is slow, and skeletal muscles gradually atrophy due to long-term lack of nerve innervation, nutrient deficiency, and lack of stimulation of nerve electrical stimulation. Neuregulin-1 (NRG-1) and epidermal growth factor receptor (ErbB) can activate multiple complex intracellular signaling networks to affect the nerves and muscles. This article reviews the regulatory effect of NRG-1/ErbB signaling pathway on peripheral nerves, muscles, and neuromuscular junctions, aiming to provide references for finding new therapeutic target for denervated muscle atrophy.
