Recent advance in quantitative susceptibility mapping in brain iron deposition associated with cognitive disorders

VernacularTitle:定量磁敏感图在认知障碍疾病脑铁沉积中的研究进展
Author: Ruohan SUN ¹ ; Yao MENG ; Xiaohua XIE ; Jing XU ; Yanhong DONG
Author Information

1. 河北医科大学研究生学院，石家庄　050017
Publication Type:Journal Article
Keywords: Quantitative susceptibility mapping; Iron deposition; Cognitive impairment; Central nervous system
From: Chinese Journal of Neuromedicine 2025;24(2):180-186
CountryChina
Language:Chinese
Abstract: Iron is involved in several activities in the brain, including energy metabolism, neurotransmitter transmission, and myelination. Disorder of peripheral iron metabolism and excessive iron accumulation in the brain can reduce cognitive and behavioral ability through pathological mechanisms such as inflammatory response and abnormal protein expression, leading to cognitive disorders. Quantitative susceptibility mapping (QSM), as a new non-invasive magnetic resonance technique, can quantitatively measure brain iron deposition, clarify the relationship between cognitive disorders and iron homeostasis imbalance, and provide a basis for clinical diagnosis and treatment of the diseases. This article reviews the latest research progress of QSM in brain iron deposition associated with cognitive disorders.