Recent advance in mesenchymal stem cell exosome in Alzheimer's disease

VernacularTitle:间充质干细胞外泌体在阿尔茨海默病中的研究进展
Author: Shijun HU ¹ ; Yumeng LI ; Tao LIU
Author Information

1. 海南医科大学附属海南医院，海南省人民医院神经内科，海口　570311
Publication Type:Journal Article
Keywords: Alzheimer's disease; Mesenchymal stem cell-derived exosome; Mesenchymal stem cell; Nano-drug; Engineered exosome; Therapeutic mechanism
From: Chinese Journal of Neuromedicine 2025;24(2):201-206
CountryChina
Language:Chinese
Abstract: Alzheimer's disease (AD) is the leading neurodegenerative disorder in the nervous system, and there is still a lack of effective therapeutic drugs. Protecting neurons and synapses is crucial in reversing AD progression. Mesenchymal stem cell-derived exosome (MSC-Exo) is rich in various stem cell components such as proteins, RNAs, and DNAs; due to its strong ability in promoting nerve repair and inhibiting neuroinflammation, MSC-Exo is expected to become a potential choice for AD treatment. This article elaborates on the biological characteristics of MSC-Exo and its application and progress in AD treatment, aiming to provide reference for translational medicine research and clinical application of MSC-Exo in AD.