The expression of nucleotide-binding oligomerization dome-like receptor protein 6 in cerebral hemorrhage of different severity and its relationship with the degree of nerve function injury
10.3760/cma.j.cn115455-20231026-00390
- VernacularTitle:不同严重程度脑出血患者核苷酸结合寡聚化结构域样受体蛋白6表达及与神经功能损伤程度的关系
- Author:
Jun LI
1
;
Xingming ZHONG
Author Information
1. 湖州康复医院神经康复科，湖州 313000
- Publication Type:Journal Article
- Keywords:
Cerebral hemorrhage;
Nucleotide-binding oligomeric dome-like receptor protein 6;
Nerve function injury
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(2):125-128
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the expression of nucleotide-binding oligomeric dome-like receptor protein 6 (NLRP6) in patients with cerebral hemorrhage of different severity and its relationship with the degree of nerve injury.Methods:A retrospective study was conducted to select 73 patients with cerebral hemorrhage admitted to Huzhou Rehabilitation Hospital from September 2021 to May 2023 as the study objects, including 20 patients with primary cerebral hemorrhage (primary group) and 53 patients with secondary cerebral hemorrhage (secondary group). The relative expression level of NLRP6 mRNA in the two groups was compared. Pearson test was used to analyze its relationship with the degree of nerve function injury.Results:The relative expression of NLRP6 mRNA in the secondary group was higher than that in the primary group: 3.14 ± 0.58 vs. 2.21 ± 0.41, there was a statistical difference ( P<0.05). The proportion of mild neurological impairment in the secondary group was lower than that in the primary group: 13.21%(7/53) vs. 50.00%(10/20), and the proportion of severe neurological impairment was higher than that in the primary group: 56.60%(30/53) vs. 30.00%(6/20), there were statistical differences ( χ2 = 4.74, 4.11, P<0.05). The relative expression of NLRP6 mRNA in mild, moderate, and severe patients in both groups was gradually increased, and the Pearson test results showed that NLRP6 was positively correlated with the degree of neurological function injury in both groups ( r = 0.614, 0.603, P<0.05). Conclusions:The relative expression of NLRP6 mRNA in patients with secondary intracerebral hemorrhage is higher than that in patients with primary intracerebral hemorrhage, and NLRP6 in patients with different types of intracerebral hemorrhage is correlated with the degree of nerve function injury.
