Vitamin K-dependent coagulation factor deficiency due to cefminox sodium
10.3760/cma.j.issn.1008-5734.2019.01.012
- VernacularTitle:头孢米诺钠致维生素K依赖性凝血因子缺乏症
- Author:
Rui ZHAO
1
;
Jingting MA
1
;
Lina WEI
1
;
Dongfu LI
1
Author Information
1. 吉林大学第二医院肝胆胰内科 长春130022
- Publication Type:Journal Article
- Keywords:
Cephamycins;
Vitamin K-dependent coagulation factor deficiency
- From:
Adverse Drug Reactions Journal
2019;21(1):59-60
- CountryChina
- Language:Chinese
-
Abstract:
A 55-year-old female patient with cholecystitis, gallstone and secondary acute pancreatitis received an Ⅳ infusion of cefminox sodium 2. 0 g twice daily. Eight days later,she developed large area of ecchymosis on her skin below the waist and abdomen,especially on that of the lower limbs. Laboratory tests showed the prothrombin time (PT)63. 0 s,prothrombin activity (PTA)0. 12,international normalized ratio (INR)5. 21,coagulation factor Ⅱ activity 0. 32,coagulation factor Ⅶ activity 0. 02,and coagulation factor X activity 0. 27. Vitamin K-dependent coagulation factor deficiency due to cefminox sodium was considered. Cefminox sodium was stopped immediately and an intramuscular injection of mephyton 10 mg once daily was given. Three days later,the laboratory tests showed PT 11. 0 s,PTA 1. 12, INR 0. 94,coagulation factor Ⅱ activity 0. 83,coagulation factor Ⅶ activity 0. 73,and coagulation factor X activity 0. 84.
