Research progress of WD repeat and FYVE domain-containing protein 1(WDFY1)
10.13431/j.cnki.immunol.j.20250042
- VernacularTitle:膜蛋白WDFY1的研究进展
- Author:
Xiaoqing ZHU
1
;
Siqi LI
;
Cheng TIAN
;
Rui HE
;
Lei FEI
;
Yongwen CHEN
;
Xiaoyong HUANG
Author Information
1. 401331,重庆医药高等专科学校科技产业发展中心
- Publication Type:Journal Article
- Keywords:
WDFY1;
Innate immune;
Neurological diseases;
Autophagy and tumors;
Rheumatoid arthritis
- From:
Immunological Journal
2025;41(4):279-284
- CountryChina
- Language:Chinese
-
Abstract:
WDFY1 is a member of the protein family containing the WD repeat and FYVE structural domains,acting as a junction that assists the recruitment of downstream molecules by Toll-like receptor 3/4(TLR3/TLR4)and promotes the body's natural anti-viral and anti-bacterial immune response.In recent years,the role of WDFY1 has been successively reported in various disease models,such as neurological diseases,autophagy and tumors.This paper aims to provide a comprehensive review of the current state of WDFY1 research,encompassing its expression distribution,cell biological function and its role in disease development,and take a prospect on the potential of WDFY1 as a target in rheumatoid arthritis.
