Nephrotic syndrome induced by tiopronin
10.3760/cma.j.issn.1008-5734.2019.01.013
- VernacularTitle:硫普罗宁致肾病综合征
- Author:
Lixin ZHANG
1
;
Kai NIU
1
Author Information
1. 河北省人民医院肾内科,石家庄,050051
- Publication Type:Journal Article
- Keywords:
Tiopronin;
Nephrotic syndrome;
Proteinuria
- From:
Adverse Drug Reactions Journal
2019;21(1):61-62
- CountryChina
- Language:Chinese
-
Abstract:
An 80-year-old male patient with lumbar vertebral tuberculosis took tiopronin (0. 2 g, thrice daily)to protect liver during chemotherapy for tuberculosis. After 7 months of treatment,eyelids and lower limbs edema appeared,then abdominal distension and urine volume decrease appeared gradually (urine volume was about 800 ml within 24 hours). Laboratory test showed that the serum total protein was 49 g/ L,albumin was 18 g/ L,urine protein was positive (+ + +),24-hour urine protein quantitation was 3720 mg (24-hour urine volume was 750 ml ). Tiopronin was stopped,antituberculotic therapy was continued,and symptomatic supportive treatments including antihypertensive,anticoagulant,diuretic,and kidney-protective therapy were given. Two weeks later,the patient′s edema disappeared,serum albumin increased to 25 g/ L,and 24-hour urine protein quantitation decreased to 1296 mg (24 hours urine volume was 1500 ml). Four weeks later,urine protein test turned negative. At 6 months of follow-up,above mentioned symptoms did not recur.
