Mendelian randomization study on the causal relationship between inflammatory factors and hepatocellular carcinoma
10.13431/j.cnki.immunol.j.20250040
- VernacularTitle:基于孟德尔随机化分析多种炎性因子与肝癌风险的关系
- Author:
Xiangqi YIN
1
;
Jinchang XIAO
;
Yuming GU
Author Information
1. 221000,徐州医科大学附属医院全科医学科
- Publication Type:Journal Article
- Keywords:
Mendelian randomization;
IL-5;
IL-17;
Hepatocellular carcinoma
- From:
Immunological Journal
2025;41(4):269-273,288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal relationship between 41 inflammatory factors and hepatocellular carcinoma(HCC).Methods A two-sample Mendelian randomization(MR)analysis was conducted using genome-wide association study(GW AS)data from the UK Biobank(GCST90043858,n=456 348)and a Finnish population-based GW AS dataset of 41 inflammatory factors(n=8 293).Genetic variants significantly associated with the 41 inflammatory factors were selected as instrumental variables(IVs).The inverse-variance weighted(IVW)method was used as the primary analysis,supplemented by MR Egger regression,weighted median method,and pleiotropy tests to ensure the robustness of the results.Results Genetically predicted IL-5(OR:2.15,95％CI:1.05-4.39,P=0.036)and IL-17(OR:3.35,95％CI:1.36-8.25,P=0.008)were significantly associated with an increased risk of liver cancer.Conclusion IL-5 and IL-17 exhibit a causal relationship with hepatocellular carcinoma risk,suggesting their potential as biomarkers for liver cancer.Targeting inflammatory signaling pathways may provide novel strategies for the prevention and treatment of HCC.
