Hypertension and elevated urinary free cortisol level caused by Anweiyang capsules(安胃疡胶囊)
10.3760/cma.j.issn.1008-5734.2019.01.014
- VernacularTitle:安胃疡胶囊致高血压及尿游离皮质醇升高
- Author:
Yueyang LI
1
;
Yan WANG
;
Hongwei ZHAO
;
Yongkai ZHANG
Author Information
1. 吉林大学第一医院药学部,长春,130021
- Publication Type:Journal Article
- Keywords:
Hypertension;
Glucocorticoids;
urine;
Glycyrrhetinic acid;
Anweiyang capsules
- From:
Adverse Drug Reactions Journal
2019;21(1):62-64
- CountryChina
- Language:Chinese
-
Abstract:
A 65-year-old male patient received oral Anweiyang capsules 0. 4 g four times daily for chronic gastritis. About 1 month after the medication,the patient developed intermittent headache, dizziness,and increased blood pressure,whose highest value was 180 / 100 mmHg. Levamlodipine besylate tablets 2. 5 mg once daily was given orally but the patient′s blood pressure was not well controlled. About 4 months later,laboratory tests showed obviously increased free cortisol in urine (2330 nmol/ 24 h),which was considered to be caused by Anweiyang capsules. Anweiyang capsules were stopped and the patient continued to take levamlodipine besylate tablets. On day 4 after the drug withdrawal,the patient′s blood pressure and urinary free cortisol began to decrease,which finally returned to normal on day 9. At 1 month of follow-up,no abnormalities were found on the blood pressure and urinary free cortisol in the patient.
